As per the researchers, the artificial polymers which are like the antibiotic peptides that need both kinds of hydrophobic as well as hydrophilic domains in the molecular structure in order to exert the antibacterial activity.
The researchers who are from Canada have got synthesized with the phosphonium polymer that can challenge this type of view. This study was published in the journal Angewandte Chemie, which is the polymer salt that has got the no hydrophobic alkyl chains but they are still acted as an extraordinary efficient biocide. For this, a re-evaluation needs to get established with the strategies in the antibiotics polymer research which needs to be necessary.
In order to combat the multiresistant bacteria, they have discovered new types of new antibiotics. It has been seen that the scientists have turned to the design as well as an exploration of the short artificial polymers as these type of polymers can get the mimic about the powerful peptide antibiotics. As per Beth Gillies and Paul J. Ragogna, along with their groups at Western University, London, ON has focused on phosphorous-containing polymers called as polyphosphonates. The molecular structure of this is consist of the hydrocarbon backbone along with the positive charge phosphorous center that is in every repeat unit. It is like the balanced display of the hydrophobic alkyl chains which have got the positive charges that are considered as essential for the effective adhesion to all types of bacterial cells as wells membrane disruptions. The scientists have already started to fine-tune the amphiphilic nature of the polyphosphonates.
It gets varied with the relative content which is based on the hydrophobic and a hydrophilic functional groups, The Western team has added the mannose sugars in the polymer. The sugar was now intended to act as the bait in order to attract the bacteria, as per authors but they have found that this plan has now got failed. The initial hypothesis is said to behave like the mannose containing phosphonium Polymer ManP. This would provide the exceptional targeted activity which is said to be incorrect. But another functional group was got success in this, as a result, they have taken the researchers by surprise.
The results shows that the hydrophobic alkyl chains have got no pivotal functional groups in order to attain the cell lysis ability which is present in the phosphonium salt polymers.