Before the onset of type 2 diabetes, women’s health is at a higher cardiometabolic risk than compared to men, as per a new study. However, the mechanisms which are responsible for such sex differences still are a mystery. The research was conducted by the researchers at Maastricht University Medical Centre. The main purpose of the study was to analyze sex-related differences in the cardiometabolic health between prediabetes and type 2 diabetes.
The protective effect can be reduced or even reversed after the onset of Type 2 diabetes in a female, thus posing a higher risk of getting affected with the cardiovascular disease. The changes in the metabolism which cause type 2 diabetes can also lead to the development of hyperglycemia. But still, there has been only a little bit of investigation conducted to know whether women stand at a higher cardiometabolic risk before getting affected with hyperglycemia.
The researchers of the study evaluated individuals aged between 40 to 70 years, which includes a higher number of people affected with type 2 diabetes. The researchers probed into the adverse differences in their cardiovascular health between before and after the onset of type 2 diabetes as well as normal glucose metabolism.
The analysis was conducted by adjusting the age, sex and the medication of individuals were needed to know whether the difference was similar or dissimilar in women and men.
The findings of the study revealed that when the subjects with prediabetes were compared with the subjects having normal glucose metabolism, women were at higher cardiometabolic risk than men. Prediabetic women were affected with high blood pressure, the adverse difference in LDL and HDL cholesterol, higher levels of a kind of fat known as triglycerides, as well as high levels of inflammation in their blood than compared to prediabetic men.
The authors of the study suggest that the most important finding of the study is that even before the onset of type 2 diabetes, there are sex-related differences in the cardiometabolic health, a disadvantage to women.
The researchers added that sex-related differences were present in certain and not all of the cardiometabolic risk factors, which were not favourable for women, were noticed in the individuals with prediabetes. This shows that women’s cardiovascular health deteriorates adversely even before the onset of type 2 diabetes, which is a factor that requires to be confirmed through prospective studies.
Hence, people should maintain a healthy lifestyle to reverse the adverse effects of type 2 diabetes.